SLE - Systemic Lupus Erythematosous

Diagnostic Criteria SLE

Malar Rash: Is a fixed erythema, flat or raised, over the nose, cheeks or forehead.



Discoid rash: Are an erythematous central patches normally raised with keratotic and scaly rims, atrophy scarring may occur.

Renal disorder: Proteinuria > 0.5 g/d, >3+ or cells casts.

Arthralgia: Joint pain in two or more peripheral joints, with tenderness, swelling or effusion.

Photophobia: Rash due UV rays.

Oral ulcers: Oral ulcers usually in the nasopharigeal region or in the oral mucose. Apthous like lessions.

Neurologic Disorder: Seizures or psychosis. Mood change.

Serositis: Pericarditis or pleuritis with effusion.

Cytopenias: Anemia, leukopenia, lymphopenia or thrombocytopenia.

ANA's: Antinuclear antibodies in serum tests or in immunofluorescence test.

Antibodies: Anti-dsDNA, Anti-SM and/or Anti-phospholipids.

If > or = 4 there is high probability to be a SLE patient with 95% sensibility and 75% specifity.

Note: the signs and symptoms could appear at any time of a well documented patient's history.

References

Harrison - Internal Medicine 17º Edition